Class 5-2 is the fifth grade elementary school classroom attended by all of the Minami-ke characters at the primary school level except Fuyuki and Touma. That is, it is attended by Chiaki, Shuuichi, Uchida, Yoshino, and Makoto. In the anime, it has a pet hamster. Its index number, 5-2, is a direct reference to kyo no go no ni (Today in Class 5-2). It serves as the setting for a variety of school-based settings. Its homeroom teacher is named Tanaka and school nurse is Kumada.
In season one, the desks are arranged in pairs, and it is implied that Makoto sits to the immediate right of Chiaki, front and center. In later seasons, the classroom reverts to a more traditional row-column arrangement, in which Chiaki sits on the middle left, by the window.